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Furthermore, inhibition of GSK-3 has been shown to prevent hyperphosphorylation of Tau in cells [Lovestone et al.Curr. Biol, 4, 1077-86 (1994); alleggra Brownlees et al.Neuroreport 8, 3251-55 (1997); Kaytor and Orr, Curr. Opin. Neurobiol, 12, 275-8 (2000)]. In transgenic mice overexpressing GSK3, significant increased Tau hyperphosphorylation and abnormal morphology of neurons were observed [Lucas et al.EMBO J, 20:27-39 (2001)].

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