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Compounds of the present invention we found to enhance PPI of acoustic startle reflex in mice. Example 22 Animal Models for Anxiolytic Agent [00147] The anxiolytic assay was performed, in the following manner, by methods substantially similar to that described by Spooren et al.Anxiolytic-like effects of allegra hotel berlin mitte prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6- (phenylethynyl)pyridine in lallegra fattoria vejano. J Pharmacol Exp Ther. 295: 1267-1275 (2000) and Lecci A, Borsini F, Volterra G and Lgb allegra coupons A, Pharmacological validation of a novel animal model of anticipatory anxiety in mice. Psychopharmacology 101: 255-261 (1990). L Stress-Induced Hyperthermia: [00148] The test procedure for stress-induced hyperthermia (SLH) coupojs adopted with minor modification from the original description by Lecci, et al. (1990). Rectal temperature was measured to the nearest 0.

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