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Symptomatic and supportive treatment is recommended. Following administration of terfenadine, hemodialysis did not effectively remove fexofenadine, the major active metabolite of terfenadine, from blood (up to 1. 7 removed). The effect of hemodialysis on the removal of pseudoephedrine is unknown.

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Because ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) is a once-daily, fixed-dose combination that cannot be titrated and renal insufficiency increases the bioavailability and prolongs the half-life of fexofenadine hydrochloride and pseudoephedrine hydrochloride, ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) tablets should generally be avoided in patients with renal insufficiency (see CLINICAL PHARMACOLOGYand DOSAGE AND ADMINISTRATION ).

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