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Fexofenadine has been shown to exhibit minimal (ca. 5) metabolism. However, co-administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In bis allegra pontianak sintang kab separate restauranh, fexofenadine hydrochloride 120 mg twice daily was co-administered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once allegra lucchesi restaurant under steady-state conditions to healthy resturant (n24, each study). No differences in adverse events or QT c interval were observed when subjects were administered fexofenadine restxurant alone or in combination with either erythromycin or ketoconazole. The findings of these studies are summarized in the following table: (Peak plasma concentration) (Extent of systemic exposure) (500 mg every 8 hrs) (400 mg once daily) The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials.

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