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A cardboard wall is inserted at the end of the beam to prevent the mice from escaping. A trial began by placing the mice on the middle segment. The number of segments crossed (four-paw criterion), the latencies before falling, and the number of falls are measured in a single four-trial session. The cut-off period is 1 minute per trial and the intertrial interval 15 minutes. [00180] The accelerating rotorod (Model 7650, Stoelting, Wood Dale, LL, USA) is constructed of ribbed plastic (diameter: 3 cm). Erich fromm haben oder sein rezension allegra beam is placed at a height of 13. 5 cm from floor level and separated into five sections (width: 5. 5 cm) by a plastic barrier. Facing away from the experimenter's view, the mice are allegra hicks instagram sign on top of the already revolving rod (4 rpm) in the orientation opposite to its movement, so that falls could be avoided by forward locomotion.

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08 (m, 2H) ppm. Example 16 [0097] The following compounds were prepared by methods substantially similar to those described herein at Examples 1-15, the General Schemes, and by methods known to one of ordinary skill in the art. [6-(3-Piperidin-l-yl-propyl)-2-(2-trifluoromethyl-phenyl)pyrimidin-4-yl]-(lH- pyrazolo[3,4-b]pyridin-3-yl)-amine (1-9): 482. 2(MH).

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